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Methods and strategies to identify markers for success, and also failure?

Investing in startups and companies early in their development carries inherent risk. What are some methods or approaches to employ to assess and mitigate risks when evaluating potential investment opportunities? 


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You may find this thread helpful. Since this is such a general question, it's very complicated to answer it. A biotech company will have different risks and opportunities vs SaaS. A pre-seed company will much riskier then a Series-B company. 

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